Woman and Man
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Extract
The primary objective of the study is to determine the molecular (DNA, RNA, protein and metabolic) changes in the tumors with reference to the obtained response in the different treatment arms. The molecular and metabolic characteristics and changes in the tumors will be evaluated by analyses of tumor samples taken before, under (if possible) and after the scheduled treatment period using: • DNA analyses, including whole genome SNP and methylation analyses in addition to RNA microarray analyses • Protein tissue arrays, protein arrays and protein kinase activity • High resolution MR magnetic angle spinning (HR-MAS) analyses The responses will be evaluated by available imaging technologies. If possible, functional imaging technologies will also be used for response evaluation: • Magnetic resonance imaging (diffusion weighted and contrast enhanced MRI) and MR spectroscopy (MRS) • PET based imaging modalities
Inclusion criteria
- Breast Cancer