Extrait

Background and study aims The first line of treatment for fungal corneal ulcers in the eye is natamycin eye. Generally such ulcers heal within 2 weeks. If they do not heal in 10-14 days another anti-fungal drug is used, such as voriconazole eye drops. However, the eye drops may not penetrate a deep lesion. Hence the aim of this study is to find out whether the injection of voriconazole into the eye is more effective than addition of another eye drop such as voriconazole in cases not responding to conventional antifungal therapy. Who can participate? Patients aged over 18 with fungal corneal ulcers not showing any signs of improvement after two weeks treatment with natamycin eye drops. What does the study involve? Participants will be randomly allocated into two groups. One group will be treated with voriconazole eye drops while the other group will be treated with voriconazole injections into the eye. What are the possible benefits and risks of participating? The benefits of enrolling are the treatment of the ulcer and the risks are slight pain and perforation of the ulcer. With both voriconazole eye drops and voriconazole injections there may be transient visual hallucinations which are reported rarely. Where is the study run from? Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (India). When is study starting and how long is it expected to run for? The study ran from December 2008 to June 2010. Who is funding the study? Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (India). Who is the main contact? Namrata Sharma, MD, DNB, MNAMS [email protected]

Critère d'inclusion

• Fungal corneal ulcer, fungal keratitis

Liens

• isrctn
• ictrp