Extrait

Background and study aims Gum Arabic (GA) is a natural product which has been used for centuries as a traditional oral hygiene substance in Arabian and African countries. Many studies have been run that support the potential activity of GA as an antiplaque agent; it is thought that it may act to prevent dental plaque formation. The present study was designed to test the effect of GA on chronic gingivitis, to assess the effect of introducing GA to a group of patients to see whether it reduces plague formation and gingivitis and compare the progress of gingivitis between a group who are given GA and a group that is given a placebo (dummy) gum. It also wants to test whether the presence of a protein called Interleukin 1 beta (IL-1β) can predict whether gum (periodontal) disease is progressing. Who can participate? Adults with mild to moderate gingivitis. What does the study involve? Participants are randomly allocated to one of two groups. After brushing their teeth, those in group 1 are asked to apply half a teaspoon of GA gently by finger to the border line between teeth and gums - the so-called dentogingival area – for around and hour and then leave it for five minutes before washing with water. Similarly, after brushing their teeth, participants in group 2 are asked to apply half a teaspoon of placebo powder gently by finger to the dentogingival area for around and hour and then leave it for five minutes before washing with water. All participants in both groups are asked to otherwise follow their usual regular oral hygiene habits. A gum disease assessment is carried out for all participants one month later and repeated after two months. What are the possible benefits and risks of participating? Not provided at time of registration Where is the study run from? Khartoum Dental Teaching Hospital (Sudan) When is the study starting and how long is it expected to run for? October 2016 to December 2016 Who is funding the study? Investigator initiated and funded Who is the main contact? 1. Dr Nazik Nurelhuda [email protected] 2. Dr Arwa Gafar [email protected]

Critère d'inclusion

• Chronic gingivitis

Liens

• isrctn