Safety Efficacy Study in 12-30y old Down Syndrome subjects Estudio de eficacia y seguridad en pacientes con sindrome de Down de 12 a 30 años de edad The primary objective of this study is as follows: ? To evaluate the efficacy of 26 weeks of treatment with RO5186582 on a composite endpoint derived from clinically meaningful responses in working me...

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A Study of RO7009789 in Combination with MPDL3280A in Patients with Locally Advanced and Metastatic Solid Tumors Estudio de RO7009789 en combinación con MPDL3280A en pacientes con tumores sólidos localmente avanzados y/o metastásicos Part IA: - safety, tolerability of sequential single-dose (SD) RO7009789 intravenous (IV) and MPDL3280A (here: MPDL) - safety, tolerability of sequential SD RO7009789 subcutaneous (SC) and MPDL - sing...

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