A Crossover Study to Evaluate Relative Bioavailability of Simeprevir Age-appropriate Oral Formulation Candidates Compared with 150-milligram (mg) Oral Capsule in Healthy Adult Participants - To compare the rate and extent of absorption of SMV following administration of a single dose of two different oral formulation candidates and following administration of a single dose of the 150-mg...

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Study to Evaluate Antiviral Activity, Safety, and Pharmacokinetics of Repeated Doses of Orally Administered JNJ 53718678 Against Respiratory Syncytial Virus Infection To evaluate the antiviral effect of repeated oral dosing of JNJ-53718678 compared to placebo in healthy adult subjects infected through inoculation with RSV-A Memphis 37b virus.

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A Study to Research what the body does with the study drug after treatment with Simeprevir, Sofosbuvir and Ledipasvir in patients with Chronic Hepatitis C Virus Genotype 1 Infection who have not yet started anti-viral treatment - To evaluate the effect of multiple-dose LDV 90 mg qd given in combination with SOF 400 mg qd on the steady-state PK of SMV 150 mg qd in chronic HCV genotype 1 infected subjects. - To evaluate the e...

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A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Multiple Doses of Orally Administered JNJ-53718678 in Infants Hospitalized with Respiratory Syncytial Virus (RSV) Infection Estudio para evaluar la farmacocinética, la seguridad y la tolerabilidad de JNJ-53718678 administrado por vía oral a lactantes hospitalizados debido a infección por el virus respiratorio sincitial (VRS) To evaluate in infants who are hospitalized with RSV infection: - the pharmacokinetics of JNJ-53718678 after multiple oral doses; - the safety and tolerability of JNJ-53718678 when administered for ...

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A Study to Evaluate Efficacy and Safety of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Fixed Dose Combination (FDC) Versus a Regimen Consisting of Darunavir/Cobicistat FDC with Emtricitabine/Tenofovir Disoproxil Fumarate FDC in Treatment-naive HIV type 1 Infected Subjects Ensayo para evaluar la eficacia y seguridad de darunavir/cobicistat/emtricitabina/tenofovir alafenamida (D/C/F/TAF) en dosis fijas combinado versus a régimen consistente en la combinación de darunavir/cobicistat en dosis fijas coadministrado junto con emtricitabina/tenofovir disoproxil fumarato en dosis fijas en sujetos naive en tratamiento antirretroviral infectados por el virus de la inmunodeficiencia humana de tipo 1 The primary objective is to demonstrate noninferiority in efficacy of a D/C/F/TAF containing once-daily single-tablet regimen versus DRV/COBI FDC combined with FTC/TDF FDC in HIV-1 infected, ARV treat...

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