ISSUE3: International Study on Syncope of Uncertain Etiology 3 ISSUE 3 is a multi-center, prospective, randomised controlled double-blind study aimed to assess the effectiveness of pacemaker therapy for prevention of asystolic neurally-mediated syncop...

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APAF: Assessment of Cardiac Resynchronization Therapy in Patients With Permanent Atrial Fibrillation A suboptimal level of resynchronization (cardiac resynchronization therapy [CRT]) achieved in many patients with actual standards and techniques based on tissue-Doppler echocardiography co...

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Guideline-based Pacing Therapy for Reflex Syncope Study hypothesis: Dual-chamber pacemaker therapy with rate-hysteresis features is effective in preventing syncopal recurrences in patients affected by cardioinhibitory (CI) forms of reflex...

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