Safety, Tolerability & PK of AZD0328 in Caucasian & Japanese This study will be performed to evaluate the safety, tolerability and pharmacokinetics of single and multiple doses of AZD0328 when administered to Japanese and Caucasian healthy male volu...

• Pays United Kingdom
• Organes Aucun
• Spécialités Aucune

Open Label Pharmacokinetic Study of OZ439 and Piperaquine on Administration of OZ439+TPGS Granules for Oral Suspension Alone or With Either Piperaquine Phosphate Tablets or Granules for Oral Solution in Healthy Volunteers A healthy volunteer study to characterise the exposure of the two study medications, following administration of OZ439 + TPGS granules with piperaquine phosphate granules (intended for chi...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Single and Multiple Ascending Dose Study With AZD9164 Given for 13 Days in Healthy Male and Female Japanese Subjects This is a single centre, Double blinded, Randomised, Placebo-controlled, Parallel group study to access the safety, tolerability, and pharmacokinetics of Inhaled AZD9164 after administrati...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

Dose-escalation Study to Assess Selumetinib Safety, Tolerability and PK The purpose of the study is to assess the safety, tolerability and PK of selumetinib (AZD6244; ARRY-142886) (Hyd-Sulfate) in healthy male Japanese and non-Japanese Asian volunteers followi...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

Food and Insulin Effect on QT/QTC Interval of ECG Moxifloxacin is routinely used as a probe to confirm assay sensitivity in thorough electrocardiogram (ECG) studies. It has been shown that a meal shortens the QT interval, which may affect...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

Japanese Single and Multiple Ascending Dose, Safety, Tolerability, Pharmacokinetic (PK) & Pharmacodynamic (PD) Study of AZD7687 This is a study in Japanese healthy volunteers to determine the safety and tolerability of the compound AZD7687. It will also assess how the body handles the drug and how it responds to th...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Comparative Bioavailability Study of Lomitapide 20 mg Intact vs Sprinkled To compare the relative bioavailability of lomitapide when administered by sprinkling the contents of a 20 mg capsule of lomitapide in applesauce or in mashed banana to a single oral intac...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

Effect of Glucose on QTc Interval in Type 1 Diabetes High blood glucose levels (hyperglycaemia) and Moxifloxacin (a commonly used antibiotic) have both been shown independently to affect heart activity in healthy volunteers as recorded by EC...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

AZD2423 Single Ascending Dose Study in Healthy Japanese Subjects This is a Phase I, single centre, randomised, double-blind, placebo-controlled, parallel group study to assess the safety, tolerability and pharmacokinetics of AZD2423 following single asc...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

Healthy Volunteer Study of the Pharmacokinetics of Oral Piperaquine With OZ439 + TPGS Formulation in the Fasted State Piperaquine tablets (coated) + OZ439 granules + TPGS granules will be co-administered in Phase IIb (adults). However, safety and PK data (for OZ439 plus piperaquine) were obtained using pi...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune