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Kusajili – Clinical trials directory
Result
of your search per sponsor: F. Hoffmann-La Roche Ltd
Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A phase II marker identification trial for Tarceva in second line NSCLC patients
The primary objective is the identification of differentially expressed genes that are predictive for benefit of Tarceva treatment.
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organs
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Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
Estudio multicéntrico, abierto, de dosis múltiples, para determinar la dosis inicial óptima de MIRCERA® administrada por vía intravenosa para el tratamiento de mantenimiento de la anemia en pacientes pediátricos con enfermedad renal crónica en Hemodiálisis
– Determinar la dosis inicial de MIRCERA® en pacientes pediátricos con ERC en hemodiálisis, que hayan sido tratados previamente durante una fase de mantenimiento de manera estable con epoetina alfa, e...
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organs
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Closed trial
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Woman Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
Study evaluating Bevacizumab in Combination with Carboplatin and Paclitaxel in Women with Metastatic, Recurrent or Persistent Cervical Cancer
To determine the safety of bevacizumab in combination with carboplatin and paclitaxel therapy for metastatic, recurrent or persistent cervical cancer, as defined by the frequency and severity of gastr...
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unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A Study of Venetoclax in combination with Cobimetinib and Venetoclax in combination with Idasanutlin in Patients aged >=60 years with Relapsed or Refractory Acute Myeloid Leukemia who are not eligible for Cytotoxic Therapy
Phase IB: • To assess the safety and tolerability of venetoclax in combination with cobimetinib (Ven+Cob), and venetoclax in combination with idasanutlin (Ven +Ida) • To determine the maximum tolera...
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unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
Estudio internacional randomizado, doble ciego, con grupos de tratamiento paralelos para evaluar la seguridad y eficacia de ocrelizumab administrado en un régimen de una o dos infusiones, comparado con placebo, en pacientes con artritis reumatoide activa que manifiestan una respuesta inadecuada a tratamiento con metotrexato. A Randomized, Double-Blind, Parallel-Group, International Study to Evaluate the Safety and Efficacy of Ocrelizumab Given as a Single Infusion or Dual Infusion Compared with Placebo in Patients with Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate Therapy
El objetivo principal de este estudio es determinar la eficacia y seguridad de una infusión única de 400 mg de ocrelizumab en combinación con MTX, frente a placebo, para reducir los signos y síntomas ...
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unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
Ensayo clínico en fase 2 de búsqueda de dosis, multicéntrico, doble- ciego, aleatorizado y controlado con placebo para investigar la eficacia, seguridad, tolerancia y farmacocinética del inhibidor de la DPP-IV, RO4876904, en pacientes con diabetes tipo 2 (BC20779). Multicenter, double-blind, randomized, placebo-controlled, dose ranging phase 2 study to investigate efficacy, safety, tolerability and pharmacokinetics of the DPP-IV inhibitor RO4876904 in patients with type 2 diabetes
Observar el cambio absoluto en HbA1c desde la valoración basal hasta el final del estudio.
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organs
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Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A study comparing bevacizumab with placebo when added to the current standard of treatment (temozolomide and radiotherapy, followed by temozolomide) in patients with a type of newly diagnosed brain tumor named Glioblastoma
• To demonstrate the superiority in overall survival (OS) when bevacizumab is added to temozolomide with radiotherapy followed by temozolomide for the treatment of patients with newly diagnosed gliobl...
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Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
Randomized, Open-label, Controlled, Multicenter, Phase III Study in Previously Untreated Patients With Unresectable Stage IIIC or Stage IV Melanoma with V600E BRAF Mutation Receiving Vemurafenib (RO5185426) or Dacarbazine
To evaluate the efficacy of RO5185426 as a monotherapy compared to dacarbazine in terms of progression free survival (PFS) and overall survival (OS) in previously untreated patients with advanced mela...
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Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
Estudio de fase I/II multicéntrico, abierto, de escalada de dosis, para evaluar la seguridad, farmacocinética y actividad de RO5083945, un anticuerpo glico-modificado anti-EGFR, en pacientes con tumores sólidos malignos metastáticos y/o localmente avanzados EGFR+. Open-label, multicenter, dose-escalation Phase I/II study to evaluate safety, pharmacokinetics and activity of RO5083945, a Glycoengineered Antibody against EGFR, in patients with metastatic and/or locally advanced malignant EGFR+ Solid Tumors
Part I of the study: - to describe the pharmacokinetics (PK) and maximum tolerated dose (MTD), if achieved, of RO5083945 in patients with metastatic and/or locally advanced malignant EGFR+ solid tumo...
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unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A multi-center, randomized, blinded, parallel-group study of the reduction of signs and symptoms during monotherapy treatment with tocilizumab 8 mg/kg intravenously versus adalimumab 40 mg subcutaneously in patients with rheumatoid arthritis
To compare the change in DAS28 from baseline to Week 24 for patients on tocilizumab (TCZ) vs adalimumab (ADA).
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organs
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Closed trial
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