Target site pharmacokinetics of linezolid after single and multiple doses in diabetes patients with soft tissue infection 1) Determination of concentrations of linezolid in plasma and the ISF of inflamed tissue and non-inflamed s.c. tissue of diabetes patients after a single dose. Tissue concentrations will be related to...

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Effects of common topical glaucoma therapy on optic nerve head blood flow autoregulation during increased arterial blood pressure and artificially elevated intraocular pressure in healthy humans To investigate the influence of common topical glaucoma therapy on ONH blood flow regulation during changes in IOP and systemic arterial blood pressure.

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Anti-inflammatory effect of statins in the human endotoxin model -To determine the effect of HMG-CoA reductase inhibitor pretreatment on inflammation and coagulation activation in human endotoxemia.

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Plasma and abscess fluid pharmacokinetics of cefpirome and moxifloxacin after single dose and multiple dose administration to measure concentrations of cefpirome and moxifloxacin in abscess fluid and abdominal cysts; describe the concentration time-curve of these agents in pus; Individual pharmacokinetic parameters will b...

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