Intensified treatment for tuberculous meningitis to reduce mortality Background and study aims Infection with bacteria called M. tuberculosis causes tuberculosis and is generally treated with a course of four or five types of antibiotic drugs. In cases of tuberculous m...

• Country None
• organs None
• Specialty None

Brief intervention for weight loss Background and study aims Obesity, a major cause of chronic disease, affects 1 in 4 adults. Even a small loss of weight is likely to reduce the risk of chronic diseases occurring, such as diabetes tha...

• Country None
• organs None
• Specialty None

The Pregnancy Physiology Pattern Prediction Study (4P Study) Background and study aims The two most recent Confidential Enquiries into Maternal Deaths reports in the UK have highlighted an urgent need to develop a national Modified Obstetric Early Warning Syste...

• Country None
• organs None
• Specialty None

Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK D) Trial: A potential new treatment for kidney disease Background and study aims Chronic Kidney Disease (CKD) affects around 10% of the population. Cardiovascular disease (CVD) is a major cause of morbidity (the relative occurrence of disease) and death i...

• Country None
• organs None
• Specialty None

Improving malaria treatment practices in children using mobile phone text-messaging in Kenya Background and study aims Implementation of the new artemether-lumefantrine treatment policy for uncomplicated malaria in Kenya is being compromised by poor treatment practices. This study aims to d...

• Country None
• organs None
• Specialty None

Adjunctive dexamethasone in HIV-infected adults with cryptococcal meningitis Background and study aims Cryptococcal meningitis (CM) causes around 625,000 deaths every year, most of which occur within 3 months of diagnosis. It is the leading cause of death in HIV patients in A...

• Country None
• organs None
• Specialty None

A randomised, open, comparison of penicillin and metronidazole for the treatment of tetanus Not provided at time of registration

• Country Bangladesh, Thailand
• organs None
• Specialty None

Home monitoring with integrated risk-stratified disease management support versus home monitoring alone in patients with heart failure Background and study aims In this study the aim is to test whether a mobile health home monitoring system, which is linked to patients’ health records and able to provide specialist alert and advice t...

• Country None
• organs None
• Specialty None

Altitude Sickness in Climbers and Efficacy of Non-steroidal anti-inflammatory drugs (NSAIDs) Trial Background and study aims Acute mountain sickness (AMS) is a common problem in people traveling higher than 2000 m in elevation. AMS involves headache, loss of muscle control, and can lead to brain s...

• Country None
• organs None
• Specialty None

A comparison of two psychological treatments for severe eating disorders Not provided at time of registration

• Country United Kingdom
• organs None
• Specialty None