A Phase II Pilot Study to Assess Safety and Efficacy of Sodium Valproate in Adults with McArdle Disease To determine whether patients taking a medicine called sodium valproate can improve muscle function expressed by an increased number of normal muscle fibres on muscle biopsy.

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A Phase II study of Gemcitabine and Bexarotene (GemBex) in the treatment of cutaneous T-cell lymphoma The primary research question is to confirm the feasibility and efficacy of using a combination of Gemcitabine and Bexarotene for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have...

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Bile salt manipulation as a novel treatment for Crohn’s disease: a single centre open label pilot study of atorvastatin and colesevalam in patients with active ileal Crohn’s disease To investigate the clinical benefit - in terms of mucosal healing and symptomatic improvement - of treatment with a combination of statins and cholestyramine (to reduce bile acid concentration) in pat...

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A randomised controlled trial of neuroprotection with lamotrigine in secondary progressive multiple sclerosis The clinical trial we are proposing directly addresses the problem that at the moment there is no treatment that can stop people with multiple sclerosis (MS) from becoming permanently disabled in the ...

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An open label, single site, 12 month, Phase II, randomised controlled trial evaluating the safety and efficacy of Exendin-4 (Exenatide) in the treatment of patients with moderate severity Parkinson's disease To collect pilot data from which to estimate the effectiveness of Exenatide in modifying the progression of the motor symptoms of patients with moderate severity of Parkinson’s disease, using a valida...

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Depletion of Serum Amyloid P Component In Alzheimer’s Disease To examine the safety, tolerability and potential effectiveness of 52 weeks exposure to CPHPC (investigational product) compared to placebo for the treatment of Alzheimer’s disease.

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Pilot of oral Sildenafil for the treatment of Pulmonary Hypertension in Thalassaemia with comparison to controls To evaluate whether 12 weeks of treatment with oral sildenafil increases Six Minute Walk Time (6MWT) distance in thalassaemia patients with Pulmonary Hypertension (PHT). Hypothesis: Mean twelve-week...

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Deep brain stimulation for severe obsessive compulsive disorder Not provided at time of registration

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The long term antibody response to CMV gB vaccine, in patients requiring liver or renal transplant The Primary objective is see the antibody levels found months to years after patients entered the randomised placebo-controlled trial of a glycoprotein B vaccine against cytomegalovirus and to have th...

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What are the indications for Prescribing ANtiDepressAnts that lead to a clinical benefit? PANDA To investigate the severity and duration of the depressive symptoms that are associated with a clinically important response (compared to placebo) to sertraline in people with depression

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