Extrait

The aim of this study is two fold a) Detection of any genetic differences between bone marrow and PBSC unrelated donors, 3-5 years post donation and confirm or refute the observations of “long-term genetic or epigenetic effects” published by Nagler et al. (completed – none detected see below) b) Screen and compare PBSC donors lymphocytes pre and up to 6 months post G-CSF exposure to detect any ‘short-term’ genetic changes also described by Nagler et al. The employment of more sensitive methods such as iFISH and gene array analysis to assess any permanent genetic changes, our primary objective, will make our study more robust.

Critère d'inclusion

• Study on the impact of stem cell donation either after mobilisation with granulocyte colony stimulating factor (GCSF) or bone marrow harvest on unrelated donors

Liens

• euctr
• ictrp