Extrait

Background and study aims A caesarean section is an operation to deliver a baby. There is a risk of heavy bleeding after caesarean section, known as postpartum haemorrhage (PPH). The aim of this study is to evaluate the effectiveness and safety of the drug carbetocin in comparison to oxytocin at preventing PPH in the third stage of labour (when the placenta is delivered) after caesarean section. Who can participate? Women with a single pregnancy undergoing cesarean delivery at term What does the study involve? Participants are randomly allocated to be treated with either intravenous (into a vein) carbetocin or intramuscular (into a muscle) oxytocin in the third stage of labour. The amount of blood lost, the need for additional drugs and blood transfusions, and adverse effects are recorded in both groups. What are the possible benefits and risks of participating? The possible benefit is control of bleeding after cesarean section, which could otherwise lead to postpartum hemorrhage with fatal outcome. There is a small risk of minor side effects. Where is the study run from? Sir Salimullah Medical College and Mitford Hospital (Bangladesh) When is the study starting and how long is it expected to run for? January to December 2015 Who is funding the study? Investigator initiated and funded Who is the main contact? 1. Prof Ferdousi Begum 2. Dr Shakila Yesmin

Critère d'inclusion

• third stage of labour

Liens

• isrctn