Extrait

During cardiac surgery, a cross-clamp is placed on the ascending aorta distal to the origin of the coronary arteries which results in complete cessation of blood flow through the myocardium. Perhexiline maleate is an anti-anginal drug that potently inhibits the mitochondrial FFA uptake enzymes CPT1 and CPT2, thus shifting myocaridal substrate metabolism from FFA to glucose. We hypothesise that preoperative loading with perhexiline in patients undergoing cardiac surgery on cardiopulmonary bypass will improve myocardial protection during cardiac surgery.

Critère d'inclusion

• Patients with left ventricular hypertrophy undergoing aortic valve surgery (with or without coronary artery surgery)

Liens

• euctr
• ictrp