Femme Homme
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Extrait
PARTS A, B1, B2: To investigate the safety and tolerability of the triplet combination (AZD2014 and palbociclib on a background of fulvestrant) in the patient groups. PART B3: To investigate the impact on exposure to AZD2014 and palbociclib when administered in the triplet combination compared to each drug without the other in the Part B3 patient group. PART C: To assess the efficacy of the triplet combination compared to the doublet combination through assessment of Progression Free Survival in the Part C patient group.
Critère d'inclusion
- Locally advanced or metastatic estrogen receptor positive breast cancer