Extrait

Tocilizumab (TCZ) is an anti-IL6 receptor monoclonal antibody. IL6 is a pro-inflammatory cytokine. Dyregulated production of this cytokine is implicated in the pathogenesis of rheumatoid arthritis (RA). It signals via the activation of key proteins - Janus kinases (JAKs) and transcription factors of the STAT family. By disrupting these pathways TCZ may be able to influence key immune cells and their function with minimal to no collateral effect on other systems. Primary Objective: To determine in patients with early, treatment naive RA, how TCZ and Methotrexate (MTX) combination or TCZ monotherapy influences key signalling pathways as well as explore other mechanisms of action including p38δ mitogen activated protein (MAP) kinase, MAP kinase kinase (MKK) 3 and MKK6. There is no information on this. These investigations will elucidate mechanism of action of TCZ/MTX and TCZ monotherapy as well as possibly identify patient subgroups that gain particular benefit from TCZ therapy.

Critère d'inclusion

• Rheumatoid Arthritis

Liens

• ictrp
• euctr