Extrait

Background and study aims Osteomyelitis is the term for bone infections. It is a difficult to cure infection and despite improvements in treatment, there has still been a steady increase in its frequency, especially in adults. Osteomyelitis commonly occurs after some sort of trauma or injury such as a fall, self-harm and violence, or road traffic injuries. Posttraumatic osteomyelitis (PTO) is a microbial (bacteria or fungi) infection of a bone which may lead to bone destruction. It is usually results from any type of trauma or an infection from the surgical treatment of the trauma that allows organisms to enter bone and cause infection. Treatment of PTO requires surgery and the use of antibiotics. There are not a lot of studies focusing on the outcomes and predictors of treatment failure of bone infection following PTO treatment. Detailed studies that address predisposing factors to recurrence of PTO are important as they may help create efficient and cost saving control measures to reduce the frequency of recurrent PTO. The aim of this study is to determine the frequency of recurrence following treatment of PTO, and identify subjects, injury, pathogen, and surgery-associated risk factors predisposing patients to recurrence of PTO. Who can participate? Adults over the age of 12 with PTO. What does the study involve? Participants are asked to join this study if they present the diagnosis of PTO, have a complete medical record and are within a minimum of one year of follow up since their diagnosis. Researchers gather data about treatment failure (such as patient comorbidities (other illnesses), injury, microbiological findings, and surgery associated variables) as well as recurrence of infection from the participant’s medical records. What are the possible benefits and risks of participating? There are no notable benefits or risks with participating. Where is the study run from? Fundação Faculdade Regional de Medicina S J Rio Preto (Brazil) When is the study starting and how long is it expected to run for? February 2007 to September 2013 Who is funding the study? Investigator funded and initiated (Brazil) Who is the main contact? 1. Dr Luciana Souza Jorge (Scientific) [email protected] 2. Prof Dr Mauro Jose Costa Salles (Scientific) [email protected]

Critère d'inclusion

• Chronic post-traumatic osteomyelitis

Liens

• isrctn