Extrait

Background and study aims It is estimated that up to 20 in 100 patients undergoing cardiac (heart) surgery have a pre-existing kidney impairment that is associated with an increased risk of death during or after the operation. Earlier studies have demonstrated that applying blood filtration (haemofiltration) within the first 48 hours after the operation halves the risk of death. The performance of the procedure two days after surgery may be too late to protect the patient's kidneys from further injury. The aim of this study is to investigate whether haemofiltration performed at the point when the patient is connected to the heart and lung bypass machine during surgery may be more beneficial. Who can participate? Patients aged 18 or over, undergoing on-pump coronary artery bypass graft surgery, and who have impaired kidney function. What does the study involve? Participants are randomly allocated into two groups. The control group undergo on-pump coronary artery bypass graft surgery without haemofiltration. The intervention group undergo on-pump coronary artery bypass graft surgery with haemofiltration. Participants are followed after the operation to determine their kidney function and length of ICU stay. What are the possible benefits and risks of participating? Not provided at time of registration Where is the study run from? Liverpool Heart & Chest Hospital NHS Foundation Trust (UK) When is the study starting and how long is it expected to run for? July 2010 to July 2011 Who is funding the study? Health Technology Assessment Programme (UK) Who is the main contact? Dr Bashir Matata [email protected]

Critère d'inclusion

• Preoperative renal impairment; coronary heart disease; cardiac artery bypass graft surgery

Liens

• ictrp
• isrctn