Femme et Homme
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Extrait
1. MTD and DLT of single agent LBH589B when administered orally, once-a-day on MWF, every week, in adult patients with advanced hematologic malignancies which has progressed despite standard therapy or for which no standard therapy exists (Arm 1) 2. MTD and DLT of single agent LBH589B when administered orally, once-a-day on MWF, every other week, in adult patients with advanced hematologic malignancies which has progressed despite standard therapy or for which no standard therapy exists (Arm 2) 3. To characterize the pharmacokinetic profile of LBH589, and its potential metabolite(s), after single and repeated doses of LBH589
Critère d'inclusion
- Advanced hematological malignancies