A Double Blind, Randomized, Placebo Controlled, Multi-Center Trial of Anti-TNFafa Chimeric Monoclonal Antibody (Infliximab, Remicade®) and Azathioprine in Patients Suffering from Systemic Lupus Erythe...

Mise à jour : Il y a 4 ans
Référence : EUCTR2005-004067-30

A Double Blind, Randomized, Placebo Controlled, Multi-Center Trial of Anti-TNFafa Chimeric Monoclonal Antibody (Infliximab, Remicade®) and Azathioprine in Patients Suffering from Systemic Lupus Erythematosus (SLE) with WHO Class V Glomerulonephritis

Femme et Homme

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Extrait

To prove that infliximab in combination with azathioprine is superior to azathioprine alone in rapidly inducing a meaningful renal improvement, defined as a reduction in proteinuria of at least 50%, in patients with membranous SLE glomerulonephritis not adequately responding to ACE inhibitors and glucocorticoids.


Critère d'inclusion

  • Systemic Lupus Erythematosus (SLE) with WHO Class V Glomerulonephritis