Extrait

PART A To determine the maximum tolerated dose (MTD) and evaluate the safety and tolerability of multiple ascending doses of VX 970 administered once weekly (Part A1) or twice weekly (Part A2) as a single agent in subjects with advanced solid tumors PART B To determine the maximum tolerated dose and evaluate the safety and tolerability of VX 970 when administered in combination with carboplatin (Part B1) and with carboplatin and paclitaxel (Part B2) in subjects with advanced solid tumors PART C To evaluate the safety and tolerability of VX 970 administered as a single agent followed by administration of VX 970 in combination with carboplatin in subjects with solid tumors and lymphoma with tumor genotypes and/or phenotypes of interest based on defects in the DDR, the mechanism of action of VX 970, and on data from ongoing clinical studies

Critère d'inclusion

• Cancer (malignant solid tumors)

Liens

• euctr
• ictrp