GDC-0973 plus vemurafenib versus vemurafenib alone in patients with unresectable stage IIIC or metastatic melanoma harboring BRAF V600 mutations

Update Il y a 4 ans
Reference: EUCTR2012-003008-11

Woman and Man

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Extract

To evaluate the efficacy of vemurafenib in combination with Cobimetinib, compared with vemurafenib and placebo, in previously untreated BRAFV600 mutation-positive patients with unresectable locally advanced or metastatic melanoma, as measured by prolongation of progression-free survival (PFS), as assessed by the study site investigator.


Inclusion criteria

  • BRAFV600-mutation positive patients with unresectable locally
  • advanced or metastatic melanoma