A Phase II study to investigate the effect of discontinuation of Dasatinib treatment in CP-CML patients with stable CMR

Mise à jour : Il y a 5 ans
Référence : EUCTR2012-001421-27

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Extrait

The primary objective of this study is to assess the rate of major molecular response (MMR), defined as BCR-ABL transcripts <0.1% on International Scale (IS) at 12 months after dasatinib discontinuation in patients who have maintained MMR without re-starting dasatinib treatment


Critère d'inclusion

  • Patients with Chronic Phase Chronic Myeloid Leukemia (CP-CML) with stable Complete Molecular Response (CMR) who have received dasatinib as first or second-line treatment for a minimum of 2 years at the time of enrollment and have confirmed dasatinib induced complete molecular remission