Extract

This phase I trial studies the side effects and best dose of palbociclib with cisplatin or carboplatin in treating patients with solid tumors that have spread to other places and usually cannot be cured or controlled with treatment. Palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving palbociclib with cisplatin or carboplatin may help stop tumor growth in patients with advanced solid tumors.

Inclusion criteria

• Solid Neoplasm,Stage III Pancreatic Cancer,Stage IIIA Breast Cancer,Stage IIIA Non-small Cell Lung Cancer,Stage IIIB Breast Cancer,Stage IIIB Non-small Cell Lung Cancer,Stage IIIC Breast Cancer,Stage IV Breast Cancer,Stage IV Non-Small Cell Lung Cancer,Stage IVA Pancreatic Cancer,Stage IVB Pancreatic Cancer,Sarcoma,Colorectal Cancer,head and neck cancer,Cancer of unknown primary,bladder cancer,Ovarian Cancer

Links

• nct