Woman and Man
- | Country : -
- | organs : -
- | Specialty : -
Extract
The PICCOLO Trial has two separate objectives. Firstly, to establish whether the toxicity of irinotecan (Ir) therapy is reduced, without loss of efficacy, by modulation with ciclosporin (Cs). Secondly, to establish whether, in patients with K-RAS wild-type tumours not previously treated with anti-EGFR therapy, the efficacy of Ir therapy is improved by the addition of panitumumab (Pan).
Inclusion criteria
- Fluorouracil-resistant advanced colorectal cancer