Femme et Homme
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Extrait
Part 1 - Quantify the concentration of aliskiren, amlodipine and angiotensin II (Ang II) in interstitial fluid (microdialysis), and quantify the concentration of aliskiren, angiotensin II and renin concentration and activity in the plasma and in the tissue (biopsy) of subcutaneous fat and skeletal muscle in hypertensive patients with abdominal obesity. Part 2 (depending on the successful results of part 1): Compare the effects of aliskiren and amlodipine on Ang II in interstitial fluid of subcutaneous fat and skeletal muscle and on RAS biomarkers in the plasma from hypertensive patients with abdominal obesity.
Critère d'inclusion
- Hypertension