A prospective phase I/II, one-arm, one-stage multi-center, open label study of lenalidomide in combination with pioglitazone, dexamethasone and metronomic low-dose chemotherapy with treosulfan in pati...

Update Il y a 5 ans
Reference: EUCTR2008-002768-32

A prospective phase I/II, one-arm, one-stage multi-center, open label study of lenalidomide in combination with pioglitazone, dexamethasone and metronomic low-dose chemotherapy with treosulfan in patients with relapsed or refractory or progressive multiple myeloma: Third-line therapy

Woman and Man

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Extract

Phase I: To determine the dose of lenalidomide to be used in phase II part of the study. Phase II: To investigate the effect of an anti-inflammatory therapy consisting of lenalidomide in combination with pioglitazone, dexamethasone and metronomic low-dose chemotherapy with treosulfan on the response rate in patients with relapsed or refractory or progressive multiple myeloma in third-line


Inclusion criteria

  • Multiple myeloma

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