Drug Interaction Between Colchicine and Calcineurin Inhibitors in Renal Graft Recipients

Update Il y a 4 ans
Reference: NCT01160276

Woman and Man

  • | Country :
  • France
  • | organs :
  • -
  • | Specialty :
  • -

Extract

Ciclosporin inhibits P-glycoprotein should increase colchicine bioavailability whereas tacrolimus should not influence colchicine disposition. This is a prospective, controlled, open labeled study performed in renal graft recipients comparing colchicine single dose (1mg) pharmacokinetics in 14 patients treated with tacrolimus and 14 patients treated with cyclosporin.


Inclusion criteria

  • Renal Replacement Therapies

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