International, multicenter, randomized (1:1 oral treprostinil (UT-15C): placebo), double-blind, placebo-controlled study in subjects with Pulmonary Arterial Hypertension (PAH) who are receiving background oral monotherapy Studio internazionale, multicentrico, randomizzato (1:1 teprostinil (UT-15C) orale : placebo), in doppio cieco, controllato verso placebo, in soggetti con ipertensione arteriosa polmonare (PHA) che ricevono la monoterapia orale di background 1.To assess the effect of oral UT-15C with PAH approved oral monotherapy compared to placebo with PAH approved oral monotherapycompared to placebo with PAH approved oral monotherapy on time to first ...

• Country None
• organs None
• Specialty None

An Open Label Extension Study of UT-15C in subjects with Pulmonary Arterial Hypertension The primary objective of this study is to provide UT-15C sustained release tablets for eligible subjects who participated in TDE-PH-310 (A Phase III, International, Multi-Center, Randomized, Double-Bl...

• Country None
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• Specialty None

A 12-Week, International, Multicenter, Double-Blind, Randomized, Placebo-Controlled Comparison of the Efficacy and Safety of Oral UT-15C Sustained Release Tablets in Subjects with Pulmonary Arterial Hypertension To assess the effect of UT-15C sustained release (SR) on exercise capacity compared to placebo (as measured by the change in 6-Minute Walk distance from Baseline to Week 12) in subjects with PAH who a...

• Country None
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• Specialty None

A 16-Week International, Multicenter, Double-Blind, Randomized, Placebo Controlled Comparison of the Efficacy and Safety of Oral UT-15C Sustained Release Tablets in Combination with an Endothelin Receptor Antagonist and/or a Phosphodiesterase-5 Inhibitor in Subjects with Pulmonary Arterial Hypertension To assess the effect of UT-15C sustained release (SR) on exercise capacity compared to placebo (as measured by the change in 6-Minute Walk distance from Baseline to Week 16) in subjects with PAH.

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Étude DIV-SCLC-301 : étude de phase 2 / 3 randomisée visant à comparer la sécurité d’emploi, la tolérance et l’efficacité du dinutuximab et de l’irinotécan avec l’irinotécan seul comme traitement de deuxième ligne chez des patients ayant un cancer du poumon à petites cellules récurrent ou réfractaire. [essai clos aux inclusions] Le cancer du poumon à petites cellules prend naissance dans les cellules qui tapissent les bronches situées au centre des poumons. Il y a deux types principaux de cancer du poumon non à petites cellul...

• Country France
• organs Poumon, type à petites cellules
• Specialty Immunothérapie - Vaccinothérapie, Chimiothérapie

DISTOL-EXT:Digital Ischaemic Lesions in Scleroderma treated with Oral Treprostinil Diethanolamine: An open-label multicenter extension study Provide, or continue to provide, treprostinil diethanolamine SR for eligible subjects who participated in protocols TDE-DU-201 or TDE-DU-301* * Protocol TDE-DU-301 is planned to be submitted at a...

• Country None
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• Specialty None

Étude DIV-SCLC-301 : étude de phase 2 / 3 randomisée visant à comparer la sécurité d’emploi, la tolérance et l’efficacité du dinutuximab et de l’irinotécan avec l’irinotécan seul comme traitement de deuxième ligne chez des patients ayant un cancer du poumon à petites cellules récurrent ou réfractaire. Le cancer du poumon à petites cellules prend naissance dans les cellules qui tapissent les bronches situées au centre des poumons. Il y a deux types principaux de cancer du poumon non à petites cellul...

• Country France
• organs Poumon, type à petites cellules
• Specialty Immunothérapie - Vaccinothérapie, Chimiothérapie

Double blind placebo controlled clinical investigation into the efficacy and tolerability of inhaled treprostinil in patients with severe pulmonary arterial hypertension To determine the effects of chronically administered, inhaled Treprostinil Sodium (TRE) on exercise capacity with an un-encouraged 6-minute walk test (6MWT) in patients with pulmonary arterial hyperte...

• Country None
• organs None
• Specialty None

DISTOL-1:Digital Ischaemic Lesions in Scleroderma treated with Oral Treprostinil Diethanolamine: A randomized, double-blind, placebo controlled, multicenter study To assess the efficacy of treprostinil diethanolamine on net ulcer burden compared to placebo in patients with systemic sclerosis (SSc)

• Country None
• organs None
• Specialty None