A trial comparing the efficacy between the two hormone drugs degarelix and triptorelin in patients having not yet entered the menopause and having not undergone surgery. Additional to each treatment the patients receive letrozole for locally advanced endocrine responsive breast cancer To evaluate the endocrine activity of neoadjuvant letrozole plus either degarelix or triptorelin.

• Country None
• organs None
• Specialty None

Phase III Trial Evaluating the Role of Adjuvant Pegylated Liposomal Doxorubicin (PLD, Caelyx®, Doxil®) for Women (age 66 years or older) with Endocrine Nonresponsive Breast Cancer Who Are NOT Suitable for Being Offered a “Standard Chemotherapy Regimen” The overall aim of the CASA trial is to investigate the role of PLD as adjuvant chemotherapy for older postmenopausal women (66 years old and above). The stratified analysis combining the results of b...

• Country None
• organs None
• Specialty None

A randomized phase III trial of exemestane versus anastrozole in postmenopausal women with receptor positive primary breast cancer To compare event free survival (EFS) between postmenopausal women treated with exemestane or anastrozole as adjuvant therapy.

• Country None
• organs None
• Specialty None

IBCSG 23-01 : Essai de phase 3 randomisé comparant un curage axillaire à l'absence de curage axillaire, chez des patientes ayant un cancer du sein. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] A randomized trial of axillary dissection versus no axillary dissection for patients with clinically node negative breast cancer and micrometastases in the sentinel node.

• Country France
• organs Sein
• Specialty Chirurgie

Étude PANACEA : étude de phase Ib/II visant à évaluer l’efficacité de MK-3475 et du trastuzumab chez des patientes ayant un cancer du sein métastatique HER2-positif résistant au trastuzumab. [essai clos aux inclusions] PANACEA : Etude de phase Ib/II visant à évaluer l’efficacité de MK-3475 et du trastuzumab chez des patientes atteintes d’un cancer du sein métastatique HER2-positif résistant au trastuzumab

• Country France
• organs Sein
• Specialty Immunothérapie - Vaccinothérapie, Thérapies Ciblées

A Phase III Trial Evaluating the Role of Chemotherapy as Adjuvant Therapy for Premenopausal Women with Endocrine Responsive Breast Cancer Who Receive Endocrine Therapy To compare ovarian function suppression plus tamoxifen or exemestane vs. chemotherapy plus ovarian function suppression plus tamoxifen or exemestane

• Country None
• organs None
• Specialty None

Étude PANACEA : étude de phase Ib/II visant à évaluer l’efficacité de MK-3475 et du trastuzumab chez des patientes ayant un cancer du sein métastatique HER2-positif résistant au trastuzumab. PANACEA : Etude de phase Ib/II visant à évaluer l’efficacité de MK-3475 et du trastuzumab chez des patientes atteintes d’un cancer du sein métastatique HER2-positif résistant au trastuzumab

• Country France
• organs Sein
• Specialty Immunothérapie - Vaccinothérapie, Thérapies Ciblées

Chemotherapy for Radically Resected Loco-regional Relapse A randomized clinical trial of adjuvant chemotherapy for radically resected loco-regional relapse of breast cancer Chemotherapy vs. Observation To evaluate the efficacy of adjuvant chemotherapy after radical local treatment of a first loco-regional recurrence of breast cancer. Treatment comparisons will be based upon the following endpoints: ...

• Country None
• organs None
• Specialty None

Phase III trial of LHRH analog administration during chemotherapy to reduce ovarian failure following chemotherapy in early stage, hormone-receptor negative breast cancer The primary objective of this study is to compare the rate of premature ovarian failure at two years following standard adjuvant or neoadjuvant chemotherapy with or without the addition of ovarian sup...

• Country None
• organs None
• Specialty None