Drug eluting balloon venoplasty in arterio-­venous fistula stenosis Background and study aims Chronic kidney disease (CKD) is a long-term condition where the kidneys do not work properly. In a healthy person, the kidneys are responsible for filtering out the waste pro...

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A Randomised, Pragmatic, Open-label study of Adalimumab versus Etanercept for Rheumatoid Arthritis To compare the proportions of people still taking adalimumab or etanercept one year after starting treatment for rheumatoid arthritis. Our objective is to determine whether adalimumab is inferior to e...

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A pharmacokinetic and pharmacodynamic study of recombinant human IGF-I (rhIGF-I) in three boys with ALS deficiency, and insulin sensitivity and bone density in patients and heterozygous first-degree relatives To determine the amount and duration of response in free IGF-1 after a single injection of rhIGF-1 in three patients with ALS deficiency due to an IGFALS gene mutation.

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A feasibility study and open pilot two-arm randomised controlled trial comparing Pressure Garment Therapy with no Pressure Garment Therapy for the prevention of abnormal scarring after burn injury Background and study aims Pressure garments are tightly fitting pieces of Lycra-based clothing which apply a constant pressure directly on the skin. They are used for patients who have had burn injuri...

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Does phosphate binding with sevelamer carbonate improve cardiovascular structure and function in patients with early chronic kidney disease? Reduction of left ventricular mass by reducing dietary phosphate intake with sevelamer carbonate

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Non-randomised trial of a lipid lowering drug and a steroid for the treatment of acute myeloblastic leukaemia Not provided at time of registration

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Myocardial protection with Perhexiline in Left Ventricular Hypertrophy During cardiac surgery, a cross-clamp is placed on the ascending aorta distal to the origin of the coronary arteries which results in complete cessation of blood flow through the myocardium. Perhexili...

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SUBMIT study: metacarpal fracture fixation Background and study aims Metacarpal fractures, commonly called broken fingers, account for about 40% of all hand injuries. Although generally surgery isn’t needed, when the break is particularly seri...

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The use of corticosteroids (Budenofalk) as a chemopreventative agent in ulcerative colitis associated neoplasia The primary outcome meaure is the methylation response of the Wnt antagonist sFRP1 measured as a binary variable (positive, negative)

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Randomised double-blind controlled trial of Perhexiline in heart failure with preserved ejection fraction syndrome (HFpEF) Not provided at time of registration

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