Extrait

An aedequate perioperative fluid therapy should be capable of replacing fluid (such as urinary output and insensible perspiration) and limited blood losses without disturbing fluid and acid-base homeostasis within the human body. With the use of state of the art crystalloids preparations we often observe the onset of a hyperchloremic acidosis with all its negative consequences like the reduction of renal function, among others. Our hypothesis is based on the Stewart model of acid-base balance where albumin and phosphate, referred to as weak acids (A-), are capable of regulating the pH. Adding sodium glycerophosphate to an established crystalloid preparation, our main objective is to stabilize the level of A- in the patient in order to maintain constant acid-base conditions.

Critère d'inclusion

• This study aims to investigate a new crystalloid fluid therapy regime for the perioperative setting providing stable fluid and acid-base homeostasis in the patient

Liens

• euctr