Extrait

This trial is studying the side effects and how well giving cyclophosphamide and busulfan followed by donor stem cell transplant works in treating patients with myelofibrosis, acute myeloid leukemia, or myelodysplastic syndrome. Giving chemotherapy, such as cyclophosphamide and busulfan, before a donor stem cell transplant helps stops the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving tacrolimus and methotrexate after the transplant may stop this from happening

Critère d'inclusion

• Adult Acute Myeloid Leukemia in Remission,Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities,Adult Acute Myeloid Leukemia With Del(5q),Adult Acute Myeloid Leukemia With Inv(16)(p13;q22),Adult Acute Myeloid Leukemia With t(15;17)(q22;q12),Adult Acute Myeloid Leukemia With t(16;16)(p13;q22),Adult Acute Myeloid Leukemia With t(8;21)(q22;q22),Childhood Acute Myeloid Leukemia in Remission,Childhood Myelodysplastic Syndromes,de Novo Myelodysplastic Syndromes,Essential Thrombocythemia,Myelodysplastic Syndrome With Isolated Del(5q),Polycythemia Vera,Previously Treated Myelodysplastic Syndromes,Primary Myelofibrosis,Recurrent Adult Acute Myeloid Leukemia,Recurrent Childhood Acute Myeloid Leukemia,secondary acute myeloid leukemia,Secondary Myelodysplastic Syndromes,Secondary Myelofibrosis,Untreated Adult Acute Myeloid Leukemia,Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

Liens

• ictrp
• nct