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A phase Ib, open-label, multi-center dose-finding study of oral panobinostat (LBH589) in combination with ara-C and mitoxantrone as salvage therapy for refractory or relapsed acute myeloid leukemia

Mise à jour : Il y a 4 ans
Référence : EUCTR2008-002986-30

Femme et Homme

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Extrait

To determine the maximum-tolerated dose (MTD) in terms of the incidence of dose-limiting toxicity (DLT) of panobinostat in combination with ara-C and mitoxantrone at a fixed dose in adult patients with relapsed or is primary refractory acute myeloid leukemia (AML).

Critère d'inclusion

  • refractory or relapsed acute myeloid leukemia

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