Extrait

Background and study aims For patients with aortic stenosis (a narrowing of the main valve out of the heart), the only effective treatment currently is valve replacement surgery. A group of drugs called ACE inhibitors are of proven benefit in treating heart failure from other causes and reducing increased heart muscle thickness, both of which occur in aortic stenosis. They are however considered to be contraindicated in aortic stenosis, despite a lack of evidence for harm. The aim of our study is to determine whether an ACE inhibitor has any beneficial effects in patients with aortic stenosis. Who can participate? Men and women aged over 18 years with aortic stenosis. What does the study involve? Participants will be randomly allocated to receive either the ACE inhibitor ramipril or a placebo (dummy) drug. What are the possible benefits and risks of participating? Not provided at time of registration. Where is the study run from? John Radcliffe Hospital (UK). When is the study starting and how long is it expected to run for? The study ran from October 2008 to December 2011. Who is funding the study? 1. Heart Research UK (UK) 2. Oxford Comprehensive NIHR Biomedical Research Centre (UK) 3. Department of Health Technology Platform Grant for Advanced Imaging (UK) Who is the main contact? Dr Saul Myerson [email protected]

Critère d'inclusion

• Cardiovascular: asymptomatic aortic stenosis

Liens

• ictrp
• isrctn