Dietary Interventions in inflammatory bowel disease (IBD)

Update Il y a 5 ans
Reference: ISRCTN17061468

Woman and Man

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Background and study aims Inflammatory bowel disease (IBD) is a term used to describe conditions which cause long-term (chronic) inflammation (swelling) in the digestive tract (gut). The two main forms of IBD are Crohn’s disease (CD) and ulcerative colitis (UC). Crohn’s disease can affect any part of the gut, but is most common at the end of the ileum (the last part of the small intestine) or the colon (the large intestine). Ulcerative colitis generally affects the colon and rectum (the last part of the large intestine). There is currently no cure for these conditions, and so the main aim of treatment is to reduce the symptoms (remission) and prevent the disease from “flaring up” and becoming active again. Even when the disease is in remission, many patients still experience 'irritable bowel syndrome-like' symptoms, such as bloating, diarrhoea and abdominal (tummy) pain. It can greatly affect their quality of life and so these symptoms need to be well managed. In recent years, the link between diet and irritable bowel syndrome-like symptoms (IBS-like symptoms) has been extensively studied. It is thought that by eating or avoiding certain foods, it is possible improve IBS-like symptoms. The aim of this study is to find out whether a particular diet which involves food restrictions can help to improve IBS-like symptoms, and whether this diet changes the composition of bacteria in the gut in patients with inflammatory bowel disease in remission. Who can participate? Adults with inactive IBD who are experiencing ‘irritable bowel syndrome-like’ symptoms. What does the study involve? Patients who meet the initial screening criteria are asked to provide a stool sample and blood sample to measure levels of inflammatory markers. They are then asked to complete a 7-day food and symptom diary. If patients remain eligible based upon the severity of symptoms in this diary, they will be asked to return to the clinic to take part in the main study. These patients go to a clinic appointment which involves completing questionnaires and providing another stool and blood sample. The participants are then randomly allocated to one of two groups. Both groups are given dietary advice however the first group is put on a diet intended to help their IBS-like symptoms and the second group are put on a diet that is not expected to have any effect on their IBS-like symptoms. Participants are then asked to follow their diets for 4 weeks, keeping a food diary in the final week. All participants then return to the clinic for a follow up appointment, where they hand in their food diaries and provide another stool and blood sample. What are the possible benefits and risks of participating? Participants may benefit from an improvement to their IBS-like symptoms as a result of their new diet. There are no specific risks of taking part although some participants may experience pain, discomfort or bruising during blood tests. Where is the study run from? Guy’s and St Thomas NHS Foundation Trust and Barts Health NHS Trust (UK) When is the study starting and how long is it expected to run for? April 2015 to December 2017 Who is funding the study? Kenneth Rainin Foundation (USA) Who is the main contact? Miss Selina Cox

Inclusion criteria

  • Topic: Gastroenterology; Subtopic: Gastroenterology; Disease: All Gastroenterology