A randomized, open-label, multicenter study evaluating thrombovascular events in subjects with cancer receiving chemotherapy and administered epoetin alfa once or three times a week for the treatment of anemia The primary objective is to compare the safety with respect to the incidence of clinically relevant and objectively confirmed TVEs in 2 dosing regimens of epoetin alfa when used following guidelines f...

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A Study to Evaluate the Dosing, Effectiveness and Safety of Topiramate for the Treatment of Epilepsy The purpose of this study is to identify patient characteristics (such as baseline seizure frequency) that may predict effective doses of topiramate using just that one drug (monotherapy) as initial t...

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Efficacy and safety following use of a novel nicotine replacement therapy. A multicenter, randomized, double blind, placebo-controlled, parallel group, 52-week study in smokers motivated to quit To evaluate the efficacy of NMS versus placebo in smokers to achieve continuous abstinence from smoking from the week 2 visit until and including the week 6, week 24, and week 52 visits, respectively.

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A study of the safety and effectiveness of EVICEL® as a treatment in addition to standard techniques of joining the colon together To evaluate the safety and effectiveness of EVICEL® Fibrin Sealant (Human) for use as an adjunct to stapled anastomosis after lower anterior resection (LAR). This will be done by assessing the abs...

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Baby Skin Care Research Programme: Baby wipes study Background and study aims We carried out our study because we have little good quality evidence about the effects of using baby cleansing wipes on young babies’ skin. Recent professional guidance stat...

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A Phase 3 Randomized, Double-Blind Study of Ceftobiprole Medocaril versus Linezolid Plus Ceftazidime in the Treatment of Nosocomial Pneumonia Clinical cure rate, defined as the ratio of the number of clinically cured subjects to the total number of subjects in the population at TOC visit.

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Comparison of two different surgical approaches to decompress lumbar spinal nerves in patients with narrow lumbar spinal canal and instability Background and study aims Spinal fusion surgery (spondylodesis) is a type of surgical procedure which joins two or more vertebrae (small bones that make up the spine) together. It is more often used t...

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A study of the efficacy and tolerability of pancrelipase microtablet (MT) capsules for the treatment of cystic fibrosis-dependent exocrine pancreatic insufficiency The purpose of this study is to assess the effectiveness and safety of oral pancrelipase MT in the treatment of adult and pediatric/adolescent cystic fibrosis (CF) patients with clinical symptoms of e...

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A comparison of the effectiveness and safety of topiramate and phenytoin in patients with new onset epilepsy requiring rapid initiation of antiepileptic drug treatment The purpose of this study is to compare the effectiveness and safety of two treatment regimens, topiramate as compared to phenytoin, in preventing seizures in patients with new-onset epilepsy who requ...

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A Study of the Effectiveness and Safety of Two Doses of Risperidone in the Treatment of Children and Adolescents With Autistic Disorder The purpose of this study is to evaluate the effectiveness (change in level of irritability and related behaviors) and safety and tolerability of the administration of 2 different fixed dose levels of...

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